منابع مشابه
Aldosterone receptor antagonists: effective but often forgotten.
A 63-year-old woman is evaluated after a recent hospitalization for an acute myocardial infarction. She reports fatigue and exertional dyspnea after ambulating 25 m. Her left ventricular (LV) ejection fraction is 38%, and her medications include aspirin, clopidogrel, a loop diuretic, an angiotensin-converting enzyme inhibitor (ACE-I), and a -adrenergic receptor antagonist. On physical examinati...
متن کاملAldosterone receptor antagonists: current perspectives and therapies
Aldosterone is a downstream effector of angiotensin II in the renin-angiotensin-aldosterone system and binds to the mineralocorticoid receptor. The classical view of aldosterone primarily acting at the level of the kidneys to regulate plasma potassium and intravascular volume status is being supplemented by evidence of new "off-target" effects of aldosterone in other organ systems. The genomic ...
متن کاملAldosterone antagonists destabilize the mineralocorticosteroid receptor.
To elucidate the mechanism of action of aldosterone antagonists, we studied the interaction of spironolactone with the chick mineralocorticosteroid receptor (MR). Intestinal cytosol contains specific spironolactone-binding sites (Kd approximately 3 nM; max. no. of binding sites approximately 100 fmol/mg of protein) that have been identified as MRs by competition experiments with steroid ligands...
متن کاملCardiovascular benefits of aldosterone receptor antagonists: what about potassium?
Before the mid-1990s, much data supported the hypothesis that the primary mechanism action of aldosterone was to maintain sodium, volume, and potassium homeostasis. This is accomplished by a direct effect on epithelial cells of the distal segments of the nephron to actively promote sodium transport out of and potassium transport into the tubular lumen. This primary mechanism of action was reinf...
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ژورنال
عنوان ژورنال: Circulation
سال: 2010
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.109.895235